Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases.

Mahvash Sadeghi, Sajad Dehnavi, Ali Asadirad, Suowen Xu, Muhammed Majeed, Tannaz Jamialahmadi, Thomas P Johnston, Amirhossein Sahebkar

Journal: Inflammopharmacology 2023;31(3):1069-1093

PMID: 36997729

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Abstract

Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed.

Address: Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.; Sabinsa Corporation, East Windsor, NJ, USA.; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected].; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected].; School of Medicine, The University of Western Australia, Perth, Australia. [email protected].; Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box, Mashhad, 91779-48564, Iran. [email protected].

DOI: 10.1007/s10787-023-01136-w

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MeSH Terms: Curcumin, Anti-Inflammatory Agents, Liver, Cytokines, Chemokines, Curcuma