Thrombocytosis in a male patient with acute promyelocytic leukaemia during all-trans retinoic (ATRA) acid treatment.

Mohmood B Aldapt, Nancy Kassem, Randa Al-Okka, Rula Ghasoub, Dina Soliman, Mohammad A Abdulla, Deena Mudawi, Feryal Ibrahim, Mohamed A Yassin

Journal: Acta bio-medica : Atenei Parmensis 2019;89(3-S):33-37

PMID: 29633731

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Abstract

We present a rather uncommon side effect observed in a 20-year-old man with acute promyelocytic leukemia during treatment with ATRA. He developed a high platelet counts reaching up to 1655×10⁹/L on day 29 of ATRA treatment, and started to recover spontaneously on day 33 of treatment, without any change in ATRA, or adding any cytoreduction therapy. No complications associated with thrombocytosis were observed. IL-6 seems to play an important role in the pathogenesis of the thrombocytosis induced by ATRA. However, it is unclear what are the precipitating factors for this rare phenomenon and whether it is caused by certain predisposing factors that might be related to patient's, disease pathogenesis or other unknown factors.

Address: Resident, Internal Medicine, Hamad Medical Corporation (HMC), Doha, Qatar. [email protected].; Clinical Pharmacist, National Center for Cancer Care and Research, Hamad Medical Corporation (HMC), Doha, Qatar. [email protected].; Specialist, Hematopathology, Laboratory Medicine, Hamad Medical Corporation (HMC) and National Cancer Institute Cairo University, Cairo, Egypt. [email protected].; Clinical Fellow, Hematology, National Center for Cancer Care and Research, Hamad Medical Corporation (HMC), Doha. [email protected].; 5 Consultant Hematopathologist Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation (HMC), Doha, Qatar. [email protected].; Consultant, Hematology, National Center for Cancer Care and Research, Hamad Medical Corporation, (HMC), Doha, Qatar. [email protected].

DOI: 10.23750/abm.v89i3-S.7218

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MeSH Terms: Bone Marrow, Ecchymosis, Humans, Interleukin-6, Leukemia, Promyelocytic, Acute, Male, Thrombocytosis, Tretinoin, Young Adult