The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy.

Vancheswaran Gopalakrishnan, Beth A Helmink, Christine N Spencer, Alexandre Reuben, Jennifer A Wargo

Journal: Cancer cell 2019;33(4):570-580

PMID: 29634945

Free Full Text on Elsevier Science View on PubMed

Abstract

The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome's influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses.

Address: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit Number 1484, 1515 Holcombe Boulevard, Houston, TX 77030, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Unit 1954, 1881 East Road, Houston, Texas 77054, USA.; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit Number 1484, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Unit 1954, 1881 East Road, Houston, Texas 77054, USA. Electronic address: [email protected].

DOI: 10.1016/j.ccell.2018.03.015

Link outs

Free resources

Full Text Sources:

Medical:

https://clinicaltrials.gov/search?term=AREA%5BRefe...

Other Literature Sources:

MeSH Terms: Bacteria, Clinical Trials as Topic, Gastrointestinal Microbiome, Humans, Immunotherapy, Monitoring, Immunologic, Neoplasms, Precision Medicine, Probiotics