Expanding lysine industry: industrial biomanufacturing of lysine and its derivatives.

Jie Cheng, Peng Chen, Andong Song, Dan Wang, Qinhong Wang

Journal: Journal of industrial microbiology & biotechnology 2019;45(8):719-734

PMID: 29654382

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Abstract

L-Lysine is widely used as a nutrition supplement in feed, food, and beverage industries as well as a chemical intermediate. At present, great efforts are made to further decrease the cost of lysine to make it more competitive in the markets. Furthermore, lysine also shows potential as a feedstock to produce other high-value chemicals for active pharmaceutical ingredients, drugs, or materials. In this review, the current biomanufacturing of lysine is first presented. Second, the production of novel derivatives from lysine is discussed. Some chemicals like L-pipecolic acid, cadaverine, and 5-aminovalerate already have been obtained at a lab scale. Others like 6-aminocaproic acid, valerolactam, and caprolactam could be produced through a biological and chemical coupling pathway or be synthesized by a hypothetical pathway. This review demonstrates an active and expansive lysine industry, and these green biomanufacturing strategies could also be applied to enhance the competitiveness of other amino acid industry.

Address: Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, Chongqing University, Chongqing, 401331, People's Republic of China.; Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.; Key Laboratory of Enzyme Engineering of Agricultural Microbiology, Ministry of Agriculture, College of Life Sciences, Henan Agricultural University, Zhengzhou, People's Republic of China.; Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, Chongqing University, Chongqing, 401331, People's Republic of China. [email protected].; Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China. [email protected].

DOI: 10.1007/s10295-018-2030-8

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MeSH Terms: Amino Acids, Amino Acids, Neutral, Aminocaproic Acid, Biocompatible Materials, Cadaverine, Caprolactam, Chemistry, Pharmaceutical, Corynebacterium glutamicum, Escherichia coli, Fermentation, Green Chemistry Technology, Industrial Microbiology, Lactams, Lysine, Pipecolic Acids, Piperidones, Polymers