Waldenström's macroglobulinemia associated with AA amyloidosis.

J Gardyn, A Schwartz, R Gal, U Lewinski, D Kristt, A M Cohen

Journal: International journal of hematology 2001;74(1):76-8

PMID: 11530809

Abstract

It is widely accepted that amyloidosis in Waldenström's macroglobulinemia (WM) is exclusively due to amyloid light-chain deposition. However, only a small number of previous reports have actually characterized the type of amyloid in WM. We now report the third patient with WM and amyloid A protein (AA) amyloidosis. This patient developed malabsorption, nephrotic syndrome, and orthostatic hypotension. AA was immunohistochemically demonstrated in the rectal biopsy. In conjunction with previous examples of AA amyloidosis, the present report raises the possibility that AA amyloidosis may also occur in WM patients.

Address: Hematology Unit, Rabin Medical Center, Petah-Tikva, Israel.

DOI: 10.1007/BF02982553

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https://medlineplus.gov/amyloidosis.html

MeSH Terms: Aged, Amyloidosis, Coloring Agents, Congo Red, Fatal Outcome, Humans, Male, Potassium Permanganate, Serum Amyloid A Protein, Waldenstrom Macroglobulinemia