Photodynamic therapy with topical photosensitizers in mucosal and semimucosal areas: Review from a dermatologic perspective.

Vieri Grandi, Maurizio Sessa, Luigi Pisano, Riccardo Rossi, Arturo Galvan, Riccardo Gattai, Moira Mori, Luana Tiradritti, Stefano Bacci, Giuliano Zuccati, Pietro Cappugi, Nicola Pimpinelli

Journal: Photodiagnosis and photodynamic therapy 2019;23():119-131

PMID: 29669264

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Abstract

Photodynamic Therapy is a procedure based on the interaction between a Photosensitizer, a light source with a specific wavelength and oxygen. The aim of this review is to provide a brief and updated analysis of scientific reports on the use of PDT with topical PS in the management of oncological, infectious, and inflammatory disorders involving mucosal and semimucosal areas, with a specific focus on diseases of dermatologic interest.

Address: University of Florence School of Health Sciences, Department of Surgical and Translational Medicine, Section of Dermatology, P. Palagi Hospital, Viale Michelangelo 41, 50125, Florence, Italy. Electronic address: [email protected].; University of Campania "Luigi Vanvitelli", Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", Via L. De Crecchio 7, Naples, Italy.; University of Florence School of Health Sciences, Department of Surgical and Translational Medicine, Section of Dermatology, P. Palagi Hospital, Viale Michelangelo 41, 50125, Florence, Italy.; Private Practice Dermatologist, C.M.R, Via S. Giovanni Bosco, 24, 36015, Schio, Italy.; University of Florence School of Health Sciences, Department of Surgical and Translational Medicine, Largo Brambilla 3, 50141, Florence, Italy.; Department of Clinical and Experimental Medicine, Research Unit of Histology and Embriology, University of Florence, 50141, Florence, Italy.

DOI: 10.1016/j.pdpdt.2018.04.005

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MeSH Terms: Anus Neoplasms, Autoimmune Diseases, Eyelid Neoplasms, Female, Heat-Shock Proteins, Humans, Infections, Inflammation, Mouth Diseases, Neoplasms, Neovascularization, Pathologic, Paget Disease, Extramammary, Photochemotherapy, Photosensitizing Agents, Singlet Oxygen, Superoxides, Up-Regulation