Foxo transcription factors in T cell biology and tumor immunity.

Chong T Luo, Ming O Li

Journal: Seminars in cancer biology 2018;50():13-20

PMID: 29684436

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Abstract

The evolutionally conserved forkhead box O (Foxo) family of transcription factors is pivotal in the control of nutrient sensing and stress responses. Recent studies have revealed that the Foxo proteins have been rewired to regulate highly specialized T cell activities. Here, we review the latest advances in the understanding of how Foxo transcription factors control T cell biology, including T cell trafficking, naive T cell homeostasis, effector and memory responses, as well as the differentiation and function of regulatory T cells. We also discuss the emerging evidence on Foxo-mediated regulation in antitumor immunity. Future work will further explore how the Foxo-dependent programs in T cells can be exploited for cancer immunotherapy.

Address: Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: [email protected].

DOI: 10.1016/j.semcancer.2018.04.006

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MeSH Terms: Cell Differentiation, Forkhead Transcription Factors, Humans, Immunotherapy, Neoplasms, Signal Transduction, T-Lymphocytes, Regulatory