The dynamin superfamily.

Rajesh Ramachandran, Sandra L Schmid

Journal: Current biology : CB 2019;28(8):R411-R416

PMID: 29689225

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Abstract

The dynamin superfamily comprises a growing assortment of multi-domain GTPases, found from bacteria to man, that are distinguished from typical GTPases of the Ras, Rab and G-protein families by their modular structure (Figure 1), relatively large size (>70 kDa), and low affinity for guanine nucleotides. In addition, they display a conserved propensity to self-assemble into polymeric arrays, the dynamics of which are regulated by an autonomous, assembly-stimulated GTPase activity.

Address: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: [email protected].; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.

DOI: 10.1016/j.cub.2017.12.013

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MeSH Terms: Amino Acid Motifs, Conserved Sequence, Dynamins, GTP Phosphohydrolases, Guanosine Triphosphate