Modern Management of Acute Liver Failure.

Ruben Khan, Sean Koppe

Journal: Gastroenterology clinics of North America 2018;47(2):313-326

PMID: 29735026

Full Text on Elsevier Science View on PubMed

Abstract

Acute liver failure is a rare but life-threatening disease that can lead to progressive encephalopathy, intracranial hypertension, and multiorgan failure. In the developed world, the most common cause remains acetaminophen overdose, but there are still many cases in which there is acute liver failure of unknown etiology. The mainstay of acute liver failure management remains supportive care in the critical care setting. If supportive treatment does not stabilize the disease process, the patient may require emergent liver transplantation. This article summarizes the current management of acute liver failure.

Address: Department of Gastroenterology and Hepatology, University of Illinois at Chicago, 840 South Wood Street, CSB Suite 718E (MC 716), Chicago, IL 60612, USA.; Department of Gastroenterology and Hepatology, University of Illinois at Chicago, 840 South Wood Street, CSB Suite 718E (MC 716), Chicago, IL 60612, USA. Electronic address: [email protected].

DOI: 10.1016/j.gtc.2018.01.005

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MeSH Terms: Acetaminophen, Acetylcysteine, Biomarkers, Blood Coagulation Disorders, Brain Diseases, Free Radical Scavengers, Humans, Intracranial Hypertension, Liver Failure, Acute, Liver Transplantation, Monitoring, Physiologic, Mushroom Poisoning, Renal Replacement Therapy