Sophoflavanones A and B, two novel prenylated flavanones from the roots of Sophora flavescens.

Hui Zhu, Ya-Nan Yang, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang

Journal: Bioorganic chemistry 2019;79():122-125

PMID: 29738971

Full Text on Elsevier Science View on PubMed

Abstract

In our ongoing investigation of the bioactive compounds from the extract of the roots of Sophora flavescens, two novel prenylated flavanones, named sophoflavanones A (1) and B (2), each with an unusual pyran ring were isolated. Their structures, as well as their absolute configurations, were elucidated based on spectroscopic data including a comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. Additionally, compounds 1 and 2 showed moderate antioxidant activities against Fe/cysteine-induced toxicity at a concentration of 0.1 µM (inhibition values of 71.65% and 72.49%, respectively, using vitamin C as a positive control (87.83%)).

Address: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China.; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guizhou 550025, PR China.; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China. Electronic address: [email protected].

DOI: 10.1016/j.bioorg.2018.04.019

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MeSH Terms: Antioxidants, Cell Line, Tumor, Flavanones, Humans, Microsomes, Liver, Plant Roots, Sophora, Stereoisomerism