Medical Therapy for Cushing's Syndrome in the Twenty-first Century.

Nicholas A Tritos, Beverly M K Biller

Journal: Endocrinology and metabolism clinics of North America 2019;47(2):427-440

PMID: 29754642

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Abstract

Medical therapy has a useful adjunctive role in many patients with Cushing's syndrome. Patients with pituitary corticotroph adenomas who have received radiation therapy to the sella require medical therapy until the effects of radiation therapy occur. In addition, patients with Cushing's syndrome who cannot undergo surgery promptly, including those who are acutely ill and cannot safely undergo tumor resection, may benefit from medical therapy as a bridge to surgery. Other possible candidates for medical therapy are those with unresectable tumors or those whose tumor location remains unknown despite adequate diagnostic evaluation.

Address: Neuroendocrine Unit, Neuroendocrine Clinical Center, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox 1, Suite 140, Boston, MA 02114, USA. Electronic address: [email protected].; Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 4, Boston, MA 02114, USA.

DOI: 10.1016/j.ecl.2018.01.006

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MeSH Terms: Antimetabolites, Antineoplastic Agents, Hormonal, Cushing Syndrome, Enzyme Inhibitors, Hormones, Humans, Neurotransmitter Agents, Receptors, Glucocorticoid