Magnesium and Drugs Commonly Used in Chronic Kidney Disease.

Jeffrey H William, Katelyn Richards, John Danziger

Journal: Advances in chronic kidney disease 2019;25(3):267-273

PMID: 29793666

Full Text on Elsevier Science View on PubMed

Abstract

As with other electrolytes, magnesium homeostasis depends on the balance between gastrointestinal absorption and kidney excretion. Certain drugs used commonly in patients with CKD can decrease gastrointestinal ingestion and kidney reclamation, and potentially cause hypomagnesemia. Other magnesium-containing drugs such as laxatives and cathartics can induce hypermagnesemia, particularly in those with impaired glomerular filtration and magnesium excretion. In this review, we will discuss the potential magnesium complications associated with a range of commonly encountered drugs in the care of CKD patients, discuss the potential mechanisms, and provide basic clinical recommendations.

Address: Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA; and Division of Transplantation, Beth Israel Deaconess Medical Center, Boston, MA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA; and Division of Transplantation, Beth Israel Deaconess Medical Center, Boston, MA. Electronic address: [email protected].

DOI: 10.1053/j.ackd.2018.01.005