Cu, a powerful positron emitter for immunoimaging and theranostic: Production via ZnO and ZnO-NPs.

Zahra Karimi, Mahdi Sadeghi, Naimeddin Mataji-Kojouri

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2018;137():56-61

PMID: 29571037

Full Text on Elsevier Science View on PubMed

Abstract

Cu is one of the most beneficial radionuclide that can be used as a theranostic agent in Positron Emission Tomography (PET) imaging. In this current work, Cu was produced with zinc oxide nanoparticles (ZnONPs) and zinc oxide powder (ZnO) via the Zn(n,p)Cu reaction in Tehran Research Reactor (TRR) and the activity values were compared with each other. The theoretical activity of Cu also was calculated with MCNPX-2.6 and the cross sections of this reaction were calculated by using TALYS-1.8, EMPIRE-3.2.2 and ALICE/ASH nuclear codes and were compared with experimental values. Transmission Electronic Microscopy (TEM), Scanning Electronic Microscopy (SEM) and X-Ray Diffraction (XRD) analysis were used for samples characterizations. From these results, it's concluded that Cu activity value with nanoscale target was achieved more than the bulk state target and had a good adaptation with the MCNPX result.

Address: Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.; Medical Physics Department, School of Medicine, Iran University of Medical Science, P.O. Box: 14155-6183, Tehran, Iran. Electronic address: [email protected].; Nuclear Science & Technology Research Institute (NSTRI), Reactor and Nuclear Safety Research School, P.O. Box: 14395-836, Tehran, Iran.

DOI: 10.1016/j.apradiso.2018.03.007