Management of Amanita phalloides poisoning: A literature review and update.

Yongzhuang Ye, Zhenning Liu

Journal: Journal of critical care 2019;46():17-22

PMID: 29627659

Full Text on Elsevier Science View on PubMed

Abstract

Amanita phalloides poisoning with a high mortality is a serious health problem in the world. The typical clinical manifestations are usually characterized by the absence of any symptoms followed by severe gastrointestinal disorders and acute liver failure. Inhibition of RNA polymeraseII (RNAP II) activity, apoptosis, and oxidative stress are considered as the major mechanism of amatoxins intoxication. The current treatment measures mainly include prevention of amatoxins absorption, elimination of absorbed amatoxins, potential antidotes therapy, and liver transplantation. Nevertheless, there are no widely accepted treatment criteria for Amanita phalloides poisoning. This paper will focus on the treatment measures based on the previous studies and provide the currently available information for clinicians.

Address: Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.; Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address: [email protected].

DOI: 10.1016/j.jcrc.2018.03.028

Link outs

Free resources

Other Literature Sources:

Subscription / membership required

Full Text Sources:

MeSH Terms: Acetylcysteine, Amanita, Amanitins, Antidotes, Bile Ducts, Charcoal, Diuresis, Gastric Lavage, Humans, Liver, Liver Failure, Acute, Liver Transplantation, Mushroom Poisoning, Penicillin G, Silymarin