Emerging Strategies on Adjuvant Therapies for Nerve Recovery.

Laviel Fernandez, David E Komatsu, Mikhail Gurevich, Lawrence C Hurst

Journal: The Journal of hand surgery 2019;43(4):368-373

PMID: 29618417

Full Text on Elsevier Science View on PubMed

Abstract

Current strategies for promoting faster and more effective peripheral nerve healing have utilized a wide variety of techniques and approaches. Nerve grafts, conduits, and stem cell therapy all have their respective advantages. However, there are still some difficulties in attaining complete functional recovery with a single treatment modality. The utilization of adjuvant treatments, in combination with current standard-of-care methods, offers the potential to improve patient outcomes. This paper highlights the current landscape of adjuvant treatments for enhancing peripheral nerve repair and regeneration.

Address: School of Medicine, Stony Brook University Hospital, Stony Brook, NY.; Department of Orthopedic Surgery, Stony Brook University Hospital, Stony Brook, NY. Electronic address: [email protected].; Department of Orthopedic Surgery, Stony Brook University Hospital, Stony Brook, NY; Department of Pharmacology, Stony Brook University, Stony Brook, NY.; Department of Orthopedic Surgery, Stony Brook University Hospital, Stony Brook, NY.

DOI: 10.1016/j.jhsa.2018.01.023

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MeSH Terms: Absorbable Implants, Allografts, Autografts, Calcium Channel Blockers, Erythropoietin, Gabapentin, Humans, Immunosuppressive Agents, Lithium Compounds, Nerve Regeneration, Neuroprotective Agents, Neurosurgical Procedures, Peripheral Nerve Injuries, Peripheral Nerves, Recovery of Function, Riluzole, Stem Cell Transplantation, Valproic Acid, Veins, Wallerian Degeneration