Morphology-dependent electrochemical behavior of 18-facet CuS nanocrystals based electrochemical sensing platform for hydrogen peroxide and prostate specific antigen.

18-facet polyhedron CuS nanocrystal and CuS sphere were prepared from CuO precursor, and CuS flower was synthesized through a simple solvothermal approach. Their electrochemical performances were investigated towards HO and it was interesting to discover that CuS nanocrystal had the best electrochemical catalysis compared with CuS sphere and CuS flower. It can deduce that the special structure of CuS nanocrystal endowed it more exposed active points, higher surface area and higher Cu/S ratio. Therefore, CuS nanocrystal was firstly employed to prepare a nonenzymatic biosensor for HO. Satisfactory results were obtained. In addition, a label-free sensing platform for prostate specific antigen (PSA) was constructed based on electrochemical catalysis towards HO of CuS nanocrystal. The label-free immunosenosr offered accurate PSA in the range of 0.001-15 ng/mL with the detection limit of 0.001 ng/mL. Besides, the immunosensor possessed good sensitivity, selectivity and stability and could detect PSA in real sample. More importantly, this work demonstrated that CuS nanocrystal hold great promising application in electrochemical sensors.

Copyright © 2018. Published by Elsevier B.V.