Iodixanol pharmacokinetics in children.

W H Johnson, T R Lloyd, B E Victorica, V R Zales, M L Epstein, R D Leff, R H Ardinger, T L Slovis, J A Johnson, P A Marsters

Journal: Pediatric cardiology 2001;22(3):223-7

PMID: 11343148

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Abstract

The objective of this report was to study the elimination pharmacokinetics of iodixanol in children. Iodixanol (Visipaque, Nycomed Inc., Wayne, PA, USA) is a new iso-osmolar iodinated radiocontrast agent. We hypothesized that elimination of this agent would be dependent on age-related differences in renal clearance. Seven centers enrolled 43 patients. Cardiac catheterization was performed in 41 patients and cranial computed tomography in 2. Patients were entered into 5 age groups: newborn to <2 months, 2 to <6 months, 6 months to <1 year, 1 to <3 years, and 3 to 6 months of age that is comparable to normal adults. Prolonged elimination in children <6 months of age is related to renal immaturity.

Address: Department of Pediatrics, LM Bargeron Division of Pediatric Cardiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. [email protected]

DOI: 10.1007/s002460010208

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MeSH Terms: Age Factors, Angiocardiography, Child, Child, Preschool, Contrast Media, Drug Interactions, Female, Humans, Infant, Infant, Newborn, Linear Models, Male, Metabolic Clearance Rate, Tomography, X-Ray Computed, Triiodobenzoic Acids