Nonribosomal peptides for iron acquisition: pyochelin biosynthesis as a case study.

Trey A Ronnebaum, Audrey L Lamb

Journal: Current opinion in structural biology 2019;53():1-11

PMID: 29455106

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Abstract

Microbes synthesize small, iron-chelating molecules known as siderophores to acquire iron from the environment. One way siderophores are generated is by nonribosomal peptide synthetases (NRPSs). The bioactive peptides generated by NRPS enzymes have unique chemical features, which are incorporated by accessory and tailoring domains or proteins. The first part of this review summarizes recent progress in NRPS structural biology. The second part uses the biosynthesis of pyochelin, a siderophore from Pseudomonas aeruginosa, as a case study to examine enzymatic methods for generating the observed diversity in NRPS-derived natural products.

Address: Department of Chemistry, University of Kansas, Lawrence, KS 66045, United States.; Department of Chemistry, University of Kansas, Lawrence, KS 66045, United States; Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, United States. Electronic address: [email protected].

DOI: 10.1016/j.sbi.2018.01.015

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MeSH Terms: Bacterial Proteins, Peptide Biosynthesis, Nucleic Acid-Independent, Peptide Synthases, Phenols, Pseudomonas aeruginosa, Thiazoles