Pentoxifylline, tocopherol, and clodronate for the treatment of mandibular osteoradionecrosis: a systematic review.

Miriam Martos-Fernández, Manel Saez-Barba, Jose López-López, Albert Estrugo-Devesa, Jose María Balibrea-Del-Castillo, Coro Bescós-Atín

Journal: Oral surgery, oral medicine, oral pathology and oral radiology 2018;125(5):431-439

PMID: 29550081

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Abstract

OBJECTIVE

The purpose of this study was to evaluate the healing benefit provided by the antioxidant and antifibrotic properties of pentoxifylline-tocopherol or pentoxifylline-tocopherol-clodronate in combination therapy for osteoradionecrosis.

STUDY DESIGN

We searched for relevant reports in PubMed by using a combination of "osteoradionecrosis" and the following keywords: "pentoxifillyne," "tocopherol," "vitamin E," or "clodronate." We considered articles in English or Spanish, with no limitations on the publication date.

RESULTS

The combination of pentoxifylline plus tocopherol with or without clodronate was found to be effective for the treatment of mandibular osteoradionecrosis, although data were generally scarce and mostly came from retrospective case series.

CONCLUSIONS

This drug therapy is well tolerated and could be promising for the treatment of mandibular osteoradionecrosis, but prospective randomized controlled clinical trials are needed for further clarification.

Address: Oral and Maxillofacial Surgery Department, Parc Taulí Hospital, Barcelona, Spain. Electronic address: [email protected].; Oral and Maxillofacial Surgery Department, Vall d'Hebron Hospital, Barcelona, Spain.; Odontostomatology Department, Dental School, University of Barcelona, Barcelona, Spain.; General and Digestive Surgery Department, Vall d'Hebron Hospital, Barcelona, Spain.

DOI: 10.1016/j.oooo.2018.02.004

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MeSH Terms: Clodronic Acid, Drug Combinations, Head and Neck Neoplasms, Humans, Mandibular Diseases, Osteoradionecrosis, Pentoxifylline, Tocopherols