Using Metabolomics to Investigate Biomarkers of Drug Addiction.

Reza Ghanbari, Susan Sumner

Journal: Trends in molecular medicine 2018;24(2):197-205

PMID: 29397321

Full Text on Elsevier Science View on PubMed

Abstract

Drug addiction has been associated with an increased risk for cancer, psychological complications, heart, liver, and lung disease, as well as infection. While genes have been identified that can mark individuals at risk for substance abuse, the initiation step of addiction is attributed to persistent metabolic disruptions occurring following the first instance of narcotic drug use. Advances in analytical technologies can enable the detection of thousands of signals in body fluids and excreta that can be used to define biochemical profiles of addiction. Today, these approaches hold promise for determining how exposure to drugs, in the absence or presence of other environmentally relevant factors, can impact human metabolism. We posit that these can lead to candidate biomarkers of drug dependence, treatment, withdrawal, or relapse.

Address: Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: [email protected].

DOI: 10.1016/j.molmed.2017.12.005

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MeSH Terms: Behavior, Addictive, Biomarkers, Humans, Metabolomics, Substance-Related Disorders