A strategy to reduce inflammation and anemia treatment's related costs in dialysis patients.

Biagio R Di Iorio, Lucia Di Micco, Luigi Russo, Luca Nardone, Emanuele De Simone, M L Sirico, Gabriella Di Natale, Domenico Russo

Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 2018;35(1):2018-vol1

PMID: 29390245

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Abstract

This is a post-hoc analysis evaluating erythropoiesis stimulating agents' (ESA) related costs while using an additional ultrafilter (Estorclean PLUS) to produce ultrapure dialysis water located within the fluid pathway after the treatment with reverse osmosis and before the dialysis machine. Twenty-nine patients (19 treated with epoetin alfa and 10 with darboepoetin alfa) were included in the analysis. We showed to gain savings of 210 € per patient (35 € per patient each month) with epoetin alfa during the experimental period of 6 months, compared to the control period and of 545 € per patient (90 € per patient each month) with darboepoetin alfa. Estorclean PLUS had a cost of 600 € (25 € per month per each patient) and was used for 6 months. Intravenous iron therapy with sodium ferrigluconate had a cost of 0,545 €/62,5 mg. In conclusion, during the experimental period with the use of Estorclean, we obtained global savings of 11 € per patient per month with epoetin alfa and 30 € per patient per month with darboepoetin alfa to treat anemia in dialysis patients.

Address: Department of Nephrology, A. Landolfi Hospital, Solofra, Avellino, Italy.; Nephrology Unit, AORN G. Moscati, Avellino, Italy.; Chair of Nephrology, University of Naples Federico II, Naples, Italy.

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MeSH Terms: Aged, Aged, 80 and over, Anemia, Cost Savings, Costs and Cost Analysis, Cross-Over Studies, Darbepoetin alfa, Distillation, Epoetin Alfa, Female, Ferric Compounds, Filtration, Hematinics, Hemodialysis Solutions, Hemoglobins, Humans, Inflammation, Kidney Failure, Chronic, Male, Middle Aged, Renal Dialysis, Water