Use of red blood cell exchange for treating acute complications of sickle cell disease.

Ilknur Kozanoglu, Hakan Ozdogu

Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2018;57(1):23-26

PMID: 29525569

Full Text on Elsevier Science View on PubMed

Abstract

Sickle cell disease (SCD) is a life-threatening chronic condition primarily caused by genetic mutation. The disease is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia. Acute complications in patients with SCD are difficult to manage due to the pathophysiological nature of the disease. Transfusion therapy is the cornerstone of management of acute complications and significantly reduces SCD morbidity and mortality. Red cell exchange (RCE), which is characterized by low iron accumulation and volume overload, has been widely used for transfusion therapy in recent years.

Address: Baskent University Medical Faculty Department of Physiology, Turkey; Baskent University Dr. Turgut Noyan Research and Training Center Apheresis Unit, Turkey.; Baskent University Dr. Turgut Noyan Research and Training Center Apheresis Unit, Turkey; Baskent University Medical Faculty Department of Hematology, Turkey. Electronic address: [email protected].

DOI: 10.1016/j.transci.2018.02.011

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MeSH Terms: Anemia, Sickle Cell, Erythrocyte Transfusion, Humans