Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum.

Qinghao Jin, Xiang Hua Han, Cheong-Yong Yun, Chul Lee, Jin Woo Lee, Dongho Lee, Mi Kyeong Lee, Sang-Hun Jung, Jin Tae Hong, Youngsoo Kim, Bang Yeon Hwang

Journal: Bioorganic & medicinal chemistry letters 2019;28(7):1252-1256

PMID: 29526485

Full Text on Elsevier Science View on PubMed

Abstract

Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1-3) along with four known compounds (4-7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Of these, compounds 4-7 dose-dependently inhibited the melanin production with the IC values ranging from 4 μM to 33 μM.

Address: College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.; School of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.; College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.; College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea. Electronic address: [email protected].

DOI: 10.1016/j.bmcl.2018.01.004

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MeSH Terms: Antineoplastic Agents, Phytogenic, Cell Line, Tumor, Cell Proliferation, Cynanchum, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Glycosides, Humans, Melanins, Melanoma, Experimental, Molecular Conformation, Plant Extracts, Plant Roots, Pregnanes, Structure-Activity Relationship