Social stress in anorexia nervosa: a review of immuno-endocrine relationships.

Anorexia nervosa (AN) patients have difficulty in establishing social contacts, leading to tension, anxiety and full-blown stress reactions. Stress hormones are chronically increased in AN, while immune function, which is involved in physical and psychological coping capacities, is mostly unimpaired. We examined immune function in a group of anorexics by measuring the T-lymphocyte proliferative response to stimulation with phytohemagglutinin (PHA), before and after in vivo acute administration of corticotropin-releasing hormone (CRH), to mirror a stress reaction. The responses of anorexics, before and after CRH stimulation, did not differ from those of controls. In a second group of anorexics, we measured plasma concentrations of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) before and after psychopharmacological (fluoxetine, amineptine) therapy. Basal values of the cytokines were not different in patients and controls, and did not change during therapy. In the same patients, we measured basal concentrations of soluble IL-1 beta receptor antagonist (s-IL-1 beta-RA), soluble IL-6 receptor (sIL-6-R) and soluble TNF-alpha receptors I and II (sTNF-alpha-R-I and -II). S-IL-1 beta-RA and sTNF-alpha-R-I and -II levels were not different in patients and controls, while those of s-IL-6-R were lower than normal in anorexics. The normality of most of the immune parameters in our anorexics, in basal conditions, after a stressful stimulation and after pharmacological manipulation of neurotransmitters suggests that the well-known interrelation among immune, neuroendocrine and central nervous system functions is not maintained in AN, the immune system being somehow unresponsive to stimuli.