The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function.

R S Blumberg, Y van de Wal, S Claypool, N Corazza, B Dickinson, E Nieuwenhuis, R Pitman, G Spiekermann, X Zhu, S Colgan, W I Lencer

Journal: Acta odontologica Scandinavica 2001;59(3):139-44

PMID: 11501882

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Abstract

The human major histocompatibility complex (MHC) on chromosome 6 encodes three classical class-I genes: human leukocyte antigens (HLA) A, B, and C. These polymorphic genes encode a 43- to 45-kDa cell surface glycoprotein that, in association with the 12-kDa beta2-microglobulin molecule, functions in the presentation of nine amino acid peptides to the T-cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells. In addition to these ubiquitously expressed, polymorphic proteins, the human genome also encodes several nonclassical MHC class-I-like, or class Ib, genes that, in general, encode nonpolymorphic molecules involved in various specific immunological functions. Many of these genes, including CD1, the neonatal Fc receptor for IgG, HLA-G, HLA-E, the MHC class-I chain-related gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology.

Address: Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [email protected]

DOI: 10.1080/000163501750266729

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MeSH Terms: CD8 Antigens, Chromosomes, Human, Pair 6, Epithelial Cells, Genes, MHC Class I, HLA Antigens, Histocompatibility Antigens Class I, Humans, Immunity, Mucosal, Killer Cells, Natural, Major Histocompatibility Complex, Membrane Glycoproteins, Receptors, Antigen, T-Cell, Receptors, Immunologic, Receptors, KIR, T-Lymphocytes, beta 2-Microglobulin