Majid Hajifaraji, Fatemeh Jahanjou, Fatemeh Abbasalizadeh, Nasser Aghamohammadzadeh, Mehran Mesgari Abbasi, Neda Dolatkhah
Journal: Asia Pacific journal of clinical nutrition 2019;27(3):581-591
PMID: 29737805
Gestational diabetes mellitus (GDM) is a common metabolic condition in pregnancy in which the pregnant woman has high serum glucose levels during gestation. It is characterised by maternal insulin resistance and is associated with inflammation throughout gestation. The aim of this study was to measure the effect of a probiotic supplement capsule containing four bacterial strains in comparison with a placebo on inflammatory and oxidative stress biomarkers among women with newly diagnosed GDM. This study is a randomised controlled trial. The patients were randomly allocated to receive either a probiotic supplement or a placebo capsule once a day for eight weeks. Results show that both inflammatory and oxidative stress biomarkers improved after the use of the probiotic supplement when compared to the placebo. The differences for two of the three inflammatory biomarkers (C-reactive protein and tumour necrosis factor-α) were statistically significant. The levels for the biomarker interlukin-6 did not change significantly between groups. Authors conclude that a probiotic supplement (containing L.acidophilus LA-5, Bifidobacterium BB-12, S.thermophilus STY-31 and L.delbrueckii bulgaricus LBY-2) improves several inflammatory and oxidative stress biomarkers in women with GDM.
BACKGROUND AND OBJECTIVES
Very little is known about the use of probiotics among pregnant women with gestational diabetes mellitus (GDM) especially its effect on oxidative stress and inflammatory indices. The aim of present study was to measure the effect of a probiotic supplement capsule on inflammation and oxidative stress biomarkers in women with newly-diagnosed GDM.
METHODS AND STUDY DESIGN
64 pregnant women with GDM were enrolled in a double-blind placebo controlled randomized clinical trial in the spring and summer of 2014. They were randomly assigned to receive either a probiotic containing four bacterial strains of Lactobacillus acidophilus LA-5, Bifidobacterium BB-12, Streptococcus Thermophilus STY-31 and Lactobacillus delbrueckii bulgaricus LBY-27 or placebo capsule for 8 consecutive weeks. Blood samples were taken pre- and post-treatment and serum indices of inflammation and oxidative stress were assayed. The measured mean response scales were then analyzed using mixed effects model. All statistical analysis was performed using Statistical Package for Social Sciences (SPSS) software (version 16).
RESULTS
Serum high-sensitivity C-reactive protein and tumor necrosis factor-α levels improved in the probiotic group to a statistically significant level over the placebo group. Serum interleukin-6 levels decreased in both groups after intervention; however, neither within group nor between group differences interleukin-6 serum levels was statistically significant. Malondialdehyde, glutathione reductase and erythrocyte glutathione peroxidase levels improved significantly with the use of probiotics when compared with the placebo.
CONCLUSIONS
The probiotic supplement containing L.acidophilus LA- 5, Bifidobacterium BB- 12, S.thermophilus STY-31 and L.delbrueckii bulgaricus LBY-2 appears to improve several inflammation and oxidative stress biomarkers in women with GDM.
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