Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma.

Muhammed Majeed, Amir Abbas Momtazi-Borojeni, Faezeh Ghasemi, Amirreza Hesari, Michele Caraglia, Amirhossein Sahebkar

Journal: Current pharmaceutical design 2019;24(19):2121-2128

PMID: 29788875

Abstract

Nasopharyngeal Cancer (NPC) is a rare type of head and neck cancer that is mainly treated by radiotherapy, but sometimes it is radioresistant. Curcumin is a polyphenolic natural product with established anticancer effects in various human cancers. Recent studies have shown that curcumin has therapeutic and radiosensitizing effects on NPC cells. In fact, it has been found that curcumin can sensitize NPC cells to radiation through different mechanisms, including modulation of ROS generation, Jab1/CSN5 and non-coding RNAs. As curcumin is safe and lacks systemic toxic effects in humans, it may be considered as a potential candidate to enhance the therapeutic effects of radiation and potentiate the efficacy of chemotherapy in the context of combination regimens.

Address: Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Biotechnology, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.; Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.; Sabinsa Corporation, East Windsor, NJ, United States.; Department of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Via L. De Crecchio 7, Naples, Italy.; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.2174/1381612824666180522105202

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MeSH Terms: Antineoplastic Agents, Biological Products, Curcumin, Humans, Molecular Structure, Nasopharyngeal Neoplasms