Incidental Detection of Dent-2 Disease in an Infant with Febrile Proteinuria.

Shpetim Salihu, Katerina Tosheska, Svetlana Cekovska, Velibor Tasic

Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2019;27(4):392-395

PMID: 29772577

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Abstract

OBJECTIVE

Febrile proteinuria is functional proteinuria and is seen as a transitory phenomenon during acute febrile illness, mainly viral infections. It is a benign phenomenon and clears promptly with resolution of the infection.

CLINICAL PRESENTATION AND INTERVENTION

In this report, we present a patient who was thought to have febrile proteinuria. Persistence of significant proteinuria after resolution of the infection prompted biochemical and genetic workup which led to the diagnosis of Dent-2 disease.

CONCLUSION

We recommend the use of SDS-PAGE (sodium dodecyl sulfate electropheresis) for the detection of low molecular weight proteinuria.

Address: Department of Neonatology, University Clinical Center, Prishtina, Kosovo.; Institute of Medical and Experimental Biochemistry, Medical School Skopje, Skopje, Macedonia.; University Children's Hospital, Medical School Skopje, Skopje, Macedonia.

DOI: 10.1159/000490147

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MeSH Terms: Blood Protein Electrophoresis, Fever, Genetic Diseases, X-Linked, Humans, Infant, Male, Nephrolithiasis, Proteinuria