Protein-derived Smart Materials for Medical Applications: Elastin-like Polypeptides.

Rui Lin, Shanshan Wang, Wentian Liu

Journal: Current pharmaceutical design 2019;24(26):3008-3013

PMID: 30179124

Abstract

A group of stimulus-responsive biopolymers developed from the hydrophobic domain of tropoelastin is collectively known as elastin-like polypeptides (ELPs). These peptides generally consist of repeated pentapeptide units of the form (VPGXG)n, where X can be any amino acid with the exception of proline. ELPs present wide-ranging possibilities in biomedicine due to their many beneficial characteristics, including tunable phase transition behavior and biological compatibility, along with the absence of immunogenic and pyrogenic characteristics. The present paper reviews the physicochemical characteristics of ELPs and outlines a range of applications in biotechnology and medicine.

Address: Department of Gastroenterology and Hepatology, Tianjin Medical University, General Hospital, Tianjin 300052, China.; School of Biological Science and Engineering, Shanxi University of Technology, Hanzhong 723001, China.

DOI: 10.2174/1381612824666180903122432

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MeSH Terms: Biomedical Research, Biotechnology, Elastin, Humans, Peptides