Structural Imaging in Atypical Parkinsonism.

Beatrice Heim, Florian Krismer, Klaus Seppi

Journal: International review of neurobiology 2019;142():67-148

PMID: 30409261

Full Text on Elsevier Science View on PubMed

Abstract

Qualitative and quantitative structural magnetic resonance imaging offer objective measures of the underlying neurodegeneration in atypical parkinsonism. Regional changes in tissue volume, signal changes and increased deposition of iron as assessed with different structural MRI techniques are surrogate markers of underlying neurodegeneration and may reflect cell loss, microglial proliferation and astroglial activation. Structural MRI has been explored as a tool to enhance diagnostic accuracy in differentiating atypical parkinsonian disorders (APDs). Moreover, the longitudinal assessment of serial structural MRI-derived parameters offers the opportunity for robust inferences regarding the progression of APDs. This review summarizes recent research findings as (1) a diagnostic tool for APDs as well as (2) as a tool to assess longitudinal changes of serial MRI-derived parameters in the different APDs.

Address: Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.; Department of Neurology, Medical University Innsbruck, Innsbruck, Austria. Electronic address: [email protected].; Department of Neurology, Medical University Innsbruck, Innsbruck, Austria; Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria. Electronic address: [email protected].

DOI: 10.1016/bs.irn.2018.08.010

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MeSH Terms: Basal Ganglia Diseases, Brain, Disease Progression, Humans, Magnetic Resonance Imaging, Neurodegenerative Diseases, Neuroimaging, Parkinsonian Disorders