Importance of Inherent Substrate Reactivity in Enzyme-Promoted Carbocation Cyclization/Rearrangements.

Dean J Tantillo

Journal: Angewandte Chemie (International ed. in English) 2019;56(34):10040-10045

PMID: 28349600

Abstract

The importance of inherent substrate reactivity for terpene synthase enzymes is discussed, with a focus on recent experimental tests of predictions derived from computations on gas-phase reactivity of carbocations.

Address: Department of Chemistry, University of California-Davis, 1 Shields Avenue, Davis, CA, 95616, USA.

DOI: 10.1002/anie.201702363

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https://doi.org/10.1002/anie.201702363

MeSH Terms: Alkyl and Aryl Transferases, Cations, Cyclization, Isotopes, Models, Chemical, Substrate Specificity, Terpenes