Tinea Capitis by Microsporum audouinii: Case Reports and Review of Published Global Literature 2000-2016.

Fábio Brito-Santos, Maria Helena Galdino Figueiredo-Carvalho, Rowena Alves Coelho, Anna Sales, Rodrigo Almeida-Paes

Journal: Mycopathologia 2018;182(11-12):1053-1060

PMID: 28736794

Abstract

Tinea capitis caused by Microsporum audouinii is reported herein from two Brazilian schoolchildren, which are brothers. Arthroconidia were evidenced on direct examination of scalp hair, and a fungus of the genus Microsporum was isolated from cultures of each patient. The isolated fungi were classified as M. audouinii by visualization of species-specific structures, including: pectinate hyphae, chlamydospores, and fusiform macroconidia, sterile growth with characteristic brown pigment in rice grains, and through DNA sequencing of the internal transcriber spacer region. Patients were refractory to ketoconazole, but the two cases had a satisfactory response to oral terbinafine. All M. audouinii infections described in this century were reviewed, and to our knowledge, this is the first literature description of this species from South America. Misidentification of M. audouinii with Microsporum canis can occur in this area, leading to erroneous data about the occurrence of this species.

Address: Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Av. Brazil 4365 - Manguinhos, 21045-900, Rio de Janeiro, RJ, Brazil.; Souza Araujo Outpatient Clinics, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.; Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Av. Brazil 4365 - Manguinhos, 21045-900, Rio de Janeiro, RJ, Brazil. [email protected].

DOI: 10.1007/s11046-017-0181-1

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MeSH Terms: Aged, Antifungal Agents, Brazil, Child, Child, Preschool, DNA, Intergenic, Drug Resistance, Fungal, Female, Hair, Humans, Ketoconazole, Male, Microbial Sensitivity Tests, Microsporum, Naphthalenes, Scalp, Skin, Terbinafine, Tinea Capitis