Structural enzymology of biotin biosynthesis.

G Schneider, Y Lindqvist

Journal: FEBS letters 2001;495(1-2):7-11

PMID: 11322938

Abstract

Over the last years, significant progress has been made in the understanding of the genetics and enzymology of the biosynthetic pathway of the vitamin biotin. The enzymes catalyzing the last four steps of this pathway, from pimeloyl-CoA to biotin, provide an ensemble of intriguing reaction mechanisms, which are presently being unravelled. The three-dimensional structures for three of these enzymes are known and provide a framework to which on-going mechanistic studies can be related.

Address: Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheelevägen 2, S-171 77, Stockholm, Sweden. [email protected].

DOI: 10.1016/s0014-5793(01)02325-0

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MeSH Terms: Acyl Coenzyme A, Acyltransferases, Amino Acids, Biotin, Carbon-Nitrogen Ligases, Enzymes, Models, Molecular, Structure-Activity Relationship, Transaminases