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Structural basis of molecular mimicry.

K W Wucherpfennig

Journal: Journal of autoimmunity 2001;16(3):293-302

PMID: 11334495

Full Text on Elsevier Science View on PubMed

Abstract

Infectious agents are thought to play an important role in the development of autoimmune diseases. Sequence similarity between infectious agents and self-proteins (molecular mimicry) has been proposed as a mechanism for the induction of autoimmunity [1]. However, it has been difficult to identify microbial peptides that activate autoreactive T cells using conventional sequence alignments. This chapter reviews progress made in the identification of such microbial peptides based on the analysis of structural features that are important for TCR recognition of MHC-bound peptides [2].

Copyright 2001 Academic Press.

Address: Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA. [email protected]
DOI: 10.1006/jaut.2000.0499

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MeSH Terms: Amino Acid Sequence, Autoimmune Diseases, Autoimmunity, Cross Reactions, Crystallography, X-Ray, HLA-DR2 Antigen, Histocompatibility Antigens Class II, Humans, Lymphocyte Activation, Molecular Mimicry, Molecular Sequence Data, Multiple Sclerosis, Myelin Basic Protein, Peptide Fragments, Receptors, Antigen, T-Cell, Structure-Activity Relationship, T-Lymphocytes, Viral Proteins
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