Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders.

Julia Knabl, Aurelia Vattai, Yao Ye, Julia Jueckstock, Stefan Hutter, Franz Kainer, Sven Mahner, Udo Jeschke

Journal: International journal of molecular sciences 2018;18(11):2340

PMID: 29113124

Abstract

Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.

Address: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany. [email protected].; Department of Obstetrics and Gynecology, Klinik Hallerwiese, 90419 Nürnberg, Germany. [email protected].; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany. [email protected].; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany. [email protected].; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany. [email protected].; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany. [email protected].; Department of Obstetrics and Gynecology, Klinik Hallerwiese, 90419 Nürnberg, Germany. [email protected].; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany. [email protected].; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany. [email protected].

DOI: 10.3390/ijms18112340

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https://scite.ai/reports/29113124

MeSH Terms: Calcitriol, Diabetes, Gestational, Female, Humans, Polymorphism, Genetic, Pregnancy, Receptors, Calcitriol, Vitamin D