Autophagy and oral cancers: A short review.

R M Chowdhury, G Singh, A Joshi, D K Singh, S Bhatia, S Goswami

Journal: Journal of stomatology, oral and maxillofacial surgery 2019;119(1):37-39

PMID: 29128597

Full Text on Elsevier Science View on PubMed

Abstract

Autophagy is a catabolic process, which involves recycling of cellular elements and it seems to play a major role in etiopathogenesis of cancers. Autophagy is thought to buffer metabolic stress, thereby aiding in cell survival. Also, it is found that inhibiting autophagy under deficient nutrition can restore cell death to apoptosis. Therefore, autophagy plays a dual role in cancer therapeutics. Globally oral cancer is a major concern of numerous deaths, so comprehensive work needs to be undertaken in the field of its progression and to determine positive treatment modalities. There exists a serious dearth of knowledge to understand and comprehend the process of autophagy, and it is beyond doubt that further research in this field would bring forth several new methods of cancer prevention and treatment.

Address: Department of Oral and Maxillofacial Pathology, Vyas Dental College and Hospital, near Kudi Haud, Pali Road, 342005 Jodhpur, Rajasthan, India. Electronic address: [email protected].; Department of Oral and Maxillofacial Pathology, Vyas Dental College and Hospital, near Kudi Haud, Pali Road, 342005 Jodhpur, Rajasthan, India. Electronic address: [email protected].; Joshi Dental Clinic, Sardarpura, Eidgah Road, 342001 Jodhpur, Rajasthan, India. Electronic address: [email protected].; Department of Oral and Maxillofacial Pathology, Vyas Dental College and Hospital, near Kudi Haud, Pali Road, 342005 Jodhpur, Rajasthan, India. Electronic address: [email protected].; Department of Oral and Maxillofacial Pathology, Vyas Dental College and Hospital, near Kudi Haud, Pali Road, 342005 Jodhpur, Rajasthan, India. Electronic address: [email protected].; Department of Oral and Maxillofacial Pathology, Vyas Dental College and Hospital, near Kudi Haud, Pali Road, 342005 Jodhpur, Rajasthan, India. Electronic address: [email protected].

DOI: 10.1016/j.jormas.2017.11.001

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MeSH Terms: Apoptosis, Autophagy, Cell Survival, Humans, Mouth Neoplasms