Effects of Exercise and Diet in Nonobese Asthma Patients-A Randomized Controlled Trial.

Louise Lindhardt Toennesen, Howraman Meteran, Morten Hostrup, Nina Rica Wium Geiker, Camilla Bjoern Jensen, Celeste Porsbjerg, Arne Astrup, Jens Bangsbo, Debbie Parker, Vibeke Backer

Journal: The journal of allergy and clinical immunology. In practice 2019;6(3):803-811

PMID: 29133220

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear.

OBJECTIVES

In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise (high-intensity interval training), diet (high protein/low glycemic index), or a combination of the 2, on asthma control and clinical outcomes in nonobese patients with asthma.

METHODS

Nonobese adult patients with asthma (n = 149) were randomized to 1 of 4 groups: an exercise group, a diet group, an exercise + diet group, or a control group. Outcomes included Asthma Control Questionnaire (ACQ) score, asthma-related quality-of-life (Asthma-Related Quality-of-Life Questionnaire [AQLQ]) score, inflammatory cell counts in induced sputum, FEV, fractional exhaled nitric oxide, and airway hyperresponsiveness (AHR).

RESULTS

A total of 125 patients completed the study and were included in the data analysis. Patients in the exercise + diet group improved the ACQ score from 1.9 ± 0.7 to 1.0 ± 0.7 and the AQLQ score from 5.2 ± 0.8 to 6.2 ± 0.7, which was statistically significant when compared with changes in the control group (P < .05 and <.01, respectively). The exercise group and the diet group did not improve either the ACQ score or the AQLQ score significantly compared with the control group and there were no significant changes in sputum cell counts, FEV, fractional exhaled nitric oxide, or AHR within any groups following the intervention period.

CONCLUSIONS

The combination of exercise and diet improves asthma control in nonobese patients, but does not affect AHR or airway inflammation.

Address: Respiratory Research Unit, Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.; Respiratory Research Unit, Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen, Denmark; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.; Clinical Nutrition Research Unit, Gentofte/Herlev University Hospital, Copenhagen, Denmark.; Department of Clinical Epidemiology, Frederiksberg Hospital, Frederiksberg, Denmark.; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; Clinical Nutrition Research Unit, Gentofte/Herlev University Hospital, Copenhagen, Denmark.; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.; Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.; Respiratory Research Unit, Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen, Denmark. Electronic address: [email protected].

DOI: 10.1016/j.jaip.2017.09.028

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MeSH Terms: Adult, Asthma, Diet, Eosinophils, Exercise Therapy, Humans, Leukocyte Count, Middle Aged, Nitric Oxide