Iron metabolism in erythroid cells and patients with congenital sideroblastic anemia.

Kazumichi Furuyama, Kiriko Kaneko

Journal: International journal of hematology 2018;107(1):44-54

PMID: 29139060

Abstract

Sideroblastic anemias are anemic disorders characterized by the presence of ring sideroblasts in a patient's bone marrow. These disorders are typically divided into two types, congenital or acquired sideroblastic anemia. Recently, several genes were reported as responsible for congenital sideroblastic anemia; however, the relationship between the function of the gene products and ring sideroblasts is largely unclear. In this review article, we will focus on the iron metabolism in erythroid cells as well as in patients with congenital sideroblastic anemia.

Address: Department of Molecular Biochemistry, Iwate Medical University, Nishitokuta 2-1-1, Yahaba, Iwate, 028-3694, Japan. [email protected].; Department of Molecular Biochemistry, Iwate Medical University, Nishitokuta 2-1-1, Yahaba, Iwate, 028-3694, Japan.

DOI: 10.1007/s12185-017-2368-0

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https://dx.doi.org/10.1007/s12185-017-2368-0

MeSH Terms: Acyl-CoA Dehydrogenase, Long-Chain, Anemia, Sideroblastic, Cerebellar Ataxia, Chromosomes, Human, X, Congenital Bone Marrow Failure Syndromes, Electron Transport Complex I, Erythroid Cells, Female, Glutaredoxins, HSP70 Heat-Shock Proteins, Heme, Humans, Iron, Lipid Metabolism, Inborn Errors, MELAS Syndrome, Male, Mitochondrial Diseases, Mitochondrial Membrane Transport Proteins, Mitochondrial Proteins, Muscular Diseases, Mutation