Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatum.

Le Ba Vinh, Nguyen Thi Minh Nguyet, Seo Young Yang, Jang Hoon Kim, Nguyen Van Thanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh, Inkyu Hwang, Young Ho Kim

Journal: Natural product research 2019;33(5):628-634

PMID: 29143535

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Abstract

Using various chromatographic separations, sixteen compounds, including one new triterpene saponin named aegicoroside A (1), were isolated from the leaves of the Vietnamese mangrove Aegiceras corniculatum. Their structures were determined by spectroscopic methods such as 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities of the isolated compounds against MCF7 (breast), HCT116 (colon), B16F10 (melanoma), and A549 (adenocarcinoma) cancer cell lines were also evaluated. Strong cytotoxicity was observed for sakurasosaponin (2) against all four cancer cell lines and for sakurasosaponin methyl ester (3) against MCF7, A549, and HCT116 cell lines with IC values ranging from 2.89 ± 0.02 to 9.86 ± 0.21 μM.

Address: a College of Pharmacy , Chungnam National University , Daejeon , Republic of Korea.; b Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.; c Korea Atomic Energy Research Institute , Jeongeup , Republic of Korea.

DOI: 10.1080/14786419.2017.1402320

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MeSH Terms: A549 Cells, Antineoplastic Agents, Phytogenic, Drug Screening Assays, Antitumor, HCT116 Cells, Humans, MCF-7 Cells, Melanoma, Experimental, Molecular Structure, Phytochemicals, Plant Leaves, Primulaceae, Saponins, Triterpenes, Vietnam