AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging.

Mario D Cordero, Matthew R Williams, Bernhard Ryffel

Journal: Trends in endocrinology and metabolism: TEM 2018;29(1):8-17

PMID: 29150317

Full Text on Elsevier Science View on PubMed

Abstract

The NLRP3 inflammasome has recently emerged as an unexpected marker of stress and metabolic risk and has also been implicated in the development of major aging-related diseases such as gout, type 2 diabetes, obesity, cancer, and neurodegenerative and cardiovascular disorders. Several pathways regulating the NLRP3 inflammasome are currently being studied, but how the NLRP3 inflammasome is regulated remains unknown. AMP-activated protein kinase (AMPK), a central regulator of multiple metabolic pathways involved in the pathophysiology of aging and age-related diseases, has emerged as an important integrator of signals controlling inflammation including the inflammasome. In this Opinion article, we show that several AMPK-dependent pathways regulate NLRP3 inflammasome activation during aging, suggesting NLRP3 as a potential pharmacological target in age-related diseases.

Address: Institute of Nutrition and Food Technology 'José Mataix Verdú', Department of Physiology, Biomedical Research Center, University of Granada, 18100 Granada, Spain. Electronic address: [email protected].; Rob Steiner Unit, Hammersmith Hospital, London W12 0NN, UK.; Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France and IDM, University of Cape Town, Cape Town, South Africa.

DOI: 10.1016/j.tem.2017.10.009

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MeSH Terms: AMP-Activated Protein Kinases, Aging, Humans, Inflammasomes, NLR Family, Pyrin Domain-Containing 3 Protein