p-cresol sulfate and indoxyl sulfate: some clouds are gathering in the uremic toxin sky.

Pieter Evenepoel, Griet Glorieux, Bjorn Meijers

Journal: Kidney international 2018;92(6):1323-1324

PMID: 29153138

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Abstract

An increasing body of experimental and clinical evidence suggests that p-cresol sulfate and indoxyl sulfate contribute to the high cardiovascular burden in patients with chronic kidney disease. In a post hoc analysis on the HEMO trial, Shafi et al. failed to confirm an association between total p-cresol sulfate and indoxyl sulfate and cardiovascular outcomes in dialysis patients. Analytical issues and case-mix may explain the discrepant findings.

Address: KUL Leuven, Department of Immunology and Microbiology, Laboratory of Nephrology, B-3000 Leuven, Belgium. Electronic address: [email protected].; Ghent University Hospital, Department of Internal Medicine, Nephrology Division, B-9000 Gent, Belgium.; KUL Leuven, Department of Immunology and Microbiology, Laboratory of Nephrology, B-3000 Leuven, Belgium.

DOI: 10.1016/j.kint.2017.06.029

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MeSH Terms: Cresols, Humans, Indican, Renal Dialysis, Sulfuric Acid Esters, Toxins, Biological, Uremia