A novel electrochemiluminescence sensor coupled with capillary electrophoresis for simultaneous determination of quinapril hydrochloride and its metabolite quinaprilat hydrochloride in human plasma.

Shuangjiao Sun, Yanfen Wei, Hao Wang, Yupin Cao, Biyang Deng

Journal: Talanta 2018;179():213-220

PMID: 29310224

Full Text on Elsevier Science View on PubMed

Abstract

A novel electrochemiluminescence (ECL) sensor with composite consisted of silica-sol, Zinc oxide nanoparticles (ZnO NPs), polyvinylpyrrolidone (PVP) and tris(2, 2'-bipyridine) ruthenium (II) was constructed. A new method for simultaneous determination of quinapril hydrochloride (QHCl) and its metabolite quinaprilat hydrochloride (QTHCl) in human plasma was developed using the ECL sensor coupled with capillary electrophoresis (CE). ECL intensities of QHCl and QTHCl increased dramatically when the ECL sensor was used as working electrode. The running buffer contains 14mmol/L phosphate (pH 8.0) and 20% n-propyl alcohol. Under optimized experimental conditions, the linearity ranges of the method are 0.007-8.0μg/mL for QHCl and 0.009-8.3μg/mL for QTHCl. The detection limits of QHCl and QTHCl (S/N=3) are 3.6ng/mL and 3.9ng/mL, respectively. The method was applied for the simultaneous determination of QHCl and QTHCl in human plasma with satisfactory results.

Address: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China; Shaoyang University, Shaoyang 422000, China.; Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.; Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China. Electronic address: [email protected].

DOI: 10.1016/j.talanta.2017.10.050

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MeSH Terms: 2,2'-Dipyridyl, Antihypertensive Agents, Biotransformation, Buffers, Calibration, Coordination Complexes, Electrochemical Techniques, Electrodes, Electrophoresis, Capillary, Humans, Limit of Detection, Luminescent Measurements, Metal Nanoparticles, Povidone, Quinapril, Silicon Dioxide, Tetrahydroisoquinolines, Zinc Oxide