Alkaloid constituents from Viola tianschanica.

Qi-Bin Chen, Haji Akber Aisa

Journal: Phytochemistry 2017;144():233-242

PMID: 28985571

Full Text on Elsevier Science View on PubMed

Abstract

Eighteen previously undescribed alkaloids, tishaviolamines A-J, including eight pairs of enantiomers, together with two known benzylisoquinoline alkaloids, (-)-bicuculline and (-)-corlumine, were isolated from Viola tianschanica. Among them, tishaviolamine A-E were demonstrated to possess three types of unpresented skeletons. The structures of these alkaloids were established by comprehensive analyses of the 1D, 2D-NMR and (+)HRESIMS data. The absolute configurations of enantiomers were determined by comparing their calculated ECD spectra with the experimental ones. The menin-mixed lineage leukemia 1 protein-protein interaction inhibitory effect of the isolated compounds were also measured.

Address: Key Laboratory of Plant Resources and Chemistry in Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China.; Key Laboratory of Plant Resources and Chemistry in Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China. Electronic address: [email protected].

DOI: 10.1016/j.phytochem.2017.09.011

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MeSH Terms: Alkaloids, Dose-Response Relationship, Drug, Histone-Lysine N-Methyltransferase, Humans, Myeloid-Lymphoid Leukemia Protein, Protein Binding, Structure-Activity Relationship, Viola