The regulation of cell polarity by lipid transfer proteins of the SEC14 family.

Marília Kf de Campos, Gabriel Schaaf

Journal: Current opinion in plant biology 2018;40():158-168

PMID: 29017091

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Abstract

SEC14 lipid transfer proteins are important regulators of phospholipid metabolism. Structural, genetic and cell biological studies in yeast suggest that they help phosphatidylinositol (PtdIns)/phosphoinositide (PIP) kinases to overcome their intrinsic inefficiency to recognize membrane-embedded substrate, thereby playing a key role in PIP homeostasis. Genomes of higher plants encode a high number and diversity of SEC14 proteins, often in combination with other domains. The Arabidopsis SEC14-Nlj16 protein AtSFH1, an important regulator of root hair development, plays an important role in the establishment of PIP microdomains. Key to this mechanism is a highly specific interaction of the Nlj16 domain with PtdIns(4,5)P and an interaction-triggered oligomerization of the protein. Nlj16/PtdIns(4,5)P interaction depends on a polybasic motif similar to those identified in other regulatory proteins.

Address: Institute of Crop Science and Resource Conservation, Department of Plant Nutrition, University of Bonn, Karlrobert-Kreiten-Strasse 13, 53115 Bonn, Germany. Electronic address: [email protected].; Institute of Crop Science and Resource Conservation, Department of Plant Nutrition, University of Bonn, Karlrobert-Kreiten-Strasse 13, 53115 Bonn, Germany. Electronic address: [email protected].

DOI: 10.1016/j.pbi.2017.09.007

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MeSH Terms: Arabidopsis, Arabidopsis Proteins, Cell Polarity, Lipid Metabolism, Phospholipid Transfer Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins