Update on investigations pertaining to the pathogenesis of biliary atresia.

Alexandra Kilgore, Cara L Mack

Journal: Pediatric surgery international 2018;33(12):1233-1241

PMID: 29063959

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Abstract

Biliary atresia is a devastating biliary disease of neonates that results in liver transplantation for the vast majority. The etiology of biliary atresia is unknown and is likely multifactorial, with components of genetic predisposition, environmental trigger and autoimmunity contributing to disease pathogenesis. This review highlights recent work related to investigations of disease pathogenesis in biliary atresia.

Address: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Digestive Health Institute, Children's Hospital Colorado, Aurora, CO, 80045, USA.; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Digestive Health Institute, Children's Hospital Colorado, Aurora, CO, 80045, USA. [email protected].

DOI: 10.1007/s00383-017-4172-6