MAGT1-mediated disturbance of Mg homeostasis lead to exhausted of HBV-infected NK and CD8 T cells.

Bo Diao, Xiaoyong Huang, Shen Guo, Chengying Yang, Guosong Liu, Yongwen Chen, Yuzhang Wu

Journal: Scientific reports 2019;7(1):13594

PMID: 29051561

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Abstract

The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium ([Mg]i) levels. It has been shown that MAGT1 was involved in the disorder in Mg homeostasis after Epstein-Barr virus (EBV) infection. Here, we identified the effects of MAGT1-mediated disturbance of Mg homeostasis on chronic hepatitis B virus (HBV)-infected natural killer (NK) and CD8 T cells. The expression of MAGT1 was gradually decreased with the increase of infected time in CD8 T cells, but not with that in NK cells, of the patients. Decreased level of intracellular free Mg ([Mg]i) leads to defective expression of programmed cell death 1 (PD-1) and the NK activating receptor (NKG2D) in NK and CD8 T cells. Our data illustrate that [Mg]i plays a key role in control of HBV infection.

Address: Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.; Magceutics, Inc, 3159 Corporate Place Hayward, California, 94545, USA.; Institute of Immunology, PLA, Third Military Medical University, Chongqing, China. [email protected].; Institute of Immunology, PLA, Third Military Medical University, Chongqing, China. [email protected].

DOI: 10.1038/s41598-017-11522-4

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https://antibodies.cancer.gov/detail/CPTC-CD8A-1

MeSH Terms: Antiviral Agents, CD8-Positive T-Lymphocytes, Cation Transport Proteins, Child, Preschool, Female, Guanine, Hepatitis B virus, Hepatitis B, Chronic, Homeostasis, Humans, Infant, Killer Cells, Natural, Magnesium, Male, NK Cell Lectin-Like Receptor Subfamily K, Programmed Cell Death 1 Receptor