Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients.

M Blomberg, S Y He, C Harwood, S T Arron, S Demehri, A Green, M M Asgari

Journal: The British journal of dermatology 2018;177(5):1225-1233

PMID: 29086412

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Abstract

Although tremendous progress has been made in recent years in skin cancer care for organ transplant recipients, significant gaps remain in data-driven clinical guidelines, particularly for the treatment and prevention of cutaneous squamous cell carcinoma (cSCC), the most common malignancy among this population. In this review, we aim to summarize current knowledge around the management of cSCC and highlight the most significant gaps in knowledge that continue to pose challenges in the delivery of skin cancer care for organ transplant recipients. We suggest future directions for research that will bridge existing gaps and establish evidence-driven guidelines for primary prevention, screening and treatment of cSCC in this high-risk patient population.

Address: Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A.; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, U.S.A.; Department of Dermatology, Weill Cornell Medical College, New York, NY, U.S.A.; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, U.K.; Department of Dermatology, University of California, San Francisco, CA, U.S.A.; QIMR Berghofer Medical Research Institute, Brisbane, Qld, Australia.; Cancer Research UK Manchester Institute, University of Manchester, Manchester, U.K.

DOI: 10.1111/bjd.15950

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MeSH Terms: Antimetabolites, Antineoplastic, Capecitabine, Carcinoma, Squamous Cell, Health Behavior, Humans, Immunosuppression Therapy, Immunosuppressive Agents, Keratoacanthoma, Neoplasm Metastasis, Niacinamide, Organ Transplantation, Papillomavirus Infections, Papillomavirus Vaccines, Photosensitivity Disorders, Quality of Life, Radiotherapy, Adjuvant, Retinoids, Skin Neoplasms, Sunlight, Transplant Recipients, Vitamin B Complex