Fluoride: A review of pre-clinical and clinical studies.

Divya Sharma, Aarti Singh, Kanika Verma, Sarvesh Paliwal, Swapnil Sharma, Jaya Dwivedi

Journal: Environmental toxicology and pharmacology 2018;56():297-313

PMID: 29091818

Full Text on Elsevier Science View on PubMed

Abstract

Fluoride is ubiquitous in environment and profound in bones, teeth and calcified tissues of human body. Fluoride has been the topic of regular discussion and investigations. Besides its toxicity, fluoride has also been examined for its beneficial effects like prevention and treatment of tooth decay, microbial infection, inflammation, cancer, occurrence of renal stone and many more. Since last many decades, several efforts have been made at pre-clinical and clinical level to understand role of fluoride in biological system. The present review gives a brief account of prevalence, sources of fluoride toxicity and pre-clinical and clinical studies carried out on effects of fluoride in last six decades.

Address: Department of Pharmacy, Banasthali University, Banasthali, India.; Department of Chemistry, Banasthali University, Banasthali, India.; Department of Pharmacy, Banasthali University, Banasthali, India. Electronic address: [email protected].

DOI: 10.1016/j.etap.2017.10.008

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MeSH Terms: Dental Caries, Drinking Water, Fluoride Poisoning, Fluorides, Humans, Polytetrafluoroethylene, Prevalence