Allograft Bone: What Is the Role of Platelet-Derived Growth Factor in Hindfoot and Ankle Fusions.

Ryan T Scott, Jeffrey E McAlister, Ryan B Rigby

Journal: Clinics in podiatric medicine and surgery 2018;35(1):37-52

PMID: 29156166

Full Text on Elsevier Science View on PubMed

Abstract

Arthrodesis of the ankle or foot is a common procedure for chronic pain and disability. Nonunion remains a prevalent complication among arthrodesis procedures. Some patients present with an inherent risk of developing a nonunion. Allograft biologics have gained popularity in an effort to reduce complications such as nonunion. Various biologics bring unique properties while maintaining a singular purpose. Platelet-derived growth factor (PDGF) may be introduced into a fusion site to facilitate healthy bony consolidation. The purpose of this article is to review the benefits and modalities of PDGF and how it can improve patient outcomes in ankle and hindfoot fusions.

Address: The CORE Institute, 18444 North 25th Avenue, Suite 210, Phoenix, AZ 85023, USA. Electronic address: [email protected].; The CORE Institute, 18444 North 25th Avenue, Suite 210, Phoenix, AZ 85023, USA.; Logan Regional Orthopedics, 1350 North 500 East, Logan, UT 84341, USA.

DOI: 10.1016/j.cpm.2017.08.008

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MeSH Terms: Adult, Aged, Allografts, Ankle Joint, Arthrodesis, Biocompatible Materials, Biological Products, Bone Transplantation, Calcium Phosphates, Female, Foot Joints, Fractures, Ununited, Humans, Male, Middle Aged, Platelet-Derived Growth Factor, Tissue Scaffolds