Connective tissue growth factor (CTGF) in age-related vascular pathologies.

Zoltan Ungvari, Marta Noa Valcarcel-Ares, Stefano Tarantini, Andriy Yabluchanskiy, Gábor A Fülöp, Tamas Kiss, Anna Csiszar

Journal: GeroScience 2018;39(5-6):491-498

PMID: 28875415

Free Full Text on PubMed Central View on PubMed

Abstract

Connective tissue growth factor (CTGF, also known as CCN2) is a matricellular protein expressed in the vascular wall, which regulates diverse cellular functions including cell adhesion, matrix production, structural remodeling, angiogenesis, and cell proliferation and differentiation. CTGF is principally regulated at the level of transcription and is induced by mechanical stresses and a number of cytokines and growth factors, including TGFβ. In this mini-review, the role of age-related dysregulation of CTGF signaling and its role in a range of macro- and microvascular pathologies, including pathogenesis of aorta aneurysms, atherogenesis, and diabetic retinopathy, are discussed. A potential role of CTGF and TGFβ in regulation and non-cell autonomous propagation of cellular senescence is also discussed.

Address: Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street, Oklahoma City, OK, 73104, USA.; Translational Geroscience Laboratory, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.; Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.; Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street, Oklahoma City, OK, 73104, USA. [email protected].; Translational Geroscience Laboratory, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. [email protected].; Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary. [email protected].

DOI: 10.1007/s11357-017-9995-5

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/olderadulthealth.html

Other Literature Sources:

https://scite.ai/reports/28875415

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-3782

Subscription / membership required

Full Text Sources:

https://doi.org/10.1007/s11357-017-9995-5

MeSH Terms: Aged, Aged, 80 and over, Aging, Atherosclerosis, Cell Differentiation, Cerebrovascular Disorders, Connective Tissue Growth Factor, Diabetic Retinopathy, Female, Humans, Male, Middle Aged, Neovascularization, Pathologic, Sensitivity and Specificity, Signal Transduction